The Mercury Target Holder at Oak Ridge National Laboratory (ORNL) is a mission-critical, fracture-critical component for the Spallation Neutron Source (SNS), where the reliability of the target assembly directly impacts facility availability. Historical target failures have been attributed to fabrication and weld defects that were not effectively identified using existing non-destructive examination (NDE) and non-destructive testing (NDT) acceptance criteria, resulting in premature component failures, unplanned facility outages, and significant replacement costs. Peregrine’s target holder design addresses these challenges by emphasizing structural integrity, joint quality, inspectability, and fracture-resistant performance throughout its service life. The design incorporates engineering principles consistent with ASME Section VIII, Division 2 requirements while supporting enhanced NDE/NDT methodologies and fracture mechanics-based assessments to improve defect characterization, establish acceptable flaw limits, and increase confidence in structural performance. By integrating robust design, manufacturing, inspection, and analytical approaches, the target holder is intended to provide a reliable, predictable, and maintainable solution capable of supporting future SNS operating conditions and extended service life requirements.